Quickbooks is available online, so they ought to work fine. Microsoft Office documents can still be a bit challenging if you're only using Google Docs/Sheets/Slides, but I believe Office Online works well on Chromebooks. If you need to access a desktop PC at home or elsewhere, there are a few good remote desktop Chrome apps. I personally have experience with using Citrix to access my hospital and clinic's electronic chart remotely, which works very well.