Hello,
I'm not real familiar with the ROMs on the HTC EVO 4G LTE but the only way you would get rid of Sense UI is with an AOSP based ROM like Cyanogen Mod ROM. Basically meaning that you would have clean Android ICS 4.x before the OEM UI/skin was added, in this case Sense. I cannot confirm if Cyanogen Mod team is supporting this device right now, but if they aren't I'm sure it will be at some point.
Otherwise all ROMs will still have Sense built into the code. You can always swap out a different launcher which doesn't require root to do, but that only changes the launcher.