Little bit of a con, but it really just is a bummer (at least until we can possibly have root access)...
I don't own any "high-end" headphones. I'm not really even an audiophile, however I got used to ARISE ViperAudio on my Nexus 6. I realize my brand spankin new V20 has amazing audio processing capabilities, but for my tastes, the ViperAudio on my Nexus 6 with my cheapie Monoprice headphones sounds better. I kinda figured that would be the case going into purchasing it. Perhaps when the B&O headphones arrive I might feel differently.
Look at it this way too. With the LCD you have much less chance of screen burn-in, as I understand it.
This is kinda a big deal to me. I had the Nexus 6 for the full time (2 years) and it shows some seriously bad burn in, I can even make out the nav buttons and what they are in most screens (when they shouldn't be there)... So considering lots of us are holding on to our phones for longer, I don't want to see any sort of burn-in later. The screen itself looks gorgeous to me as well, better than the Note 4 and much better looking than the Nexus 6.