My answer is no. I'm running CM, and I cannot see any reason to upgrade. All the developers (Pete, Koush, AdamZ, Chevy, etc) will be moving the 2.1 features into the new roms, so there is no reason to upgrade.
Just wait for the next ROM upgrade for your respective ROM, that should be the Droid ESE81 build, with all the rooted features.
Long story short: just wait a week, you'll get an update to your current ROM.
No problem . I just noticed, if you want to switch ROM's, Koush is offering the baseband for 2.1 right now through ROM Manager.
But, again, just wait and everything should be updated in a week. Especially since I think Pete (Bugless Beast) already rooted the phone (he's offering a 2.1 download and claims it's already rooted). I can't wait!
Edit: Also just noticed that Pete is offering the radio update for BB Version 0.9 through ROM manager as well.