When I was playing with my classmates Droid X, the Hump actually helps fishing it out of a pocket. That and out of bags. I quite enjoy it. As for the physical buttons:
Since I was on a G1 from March 2009 to March 2011, I have to say, anything physical, allowed more to be done on the screen. I say this, because since I activated and started using my Interim-droid, I find the capacitive buttons not nearly as responsive as i'd like them to be, and they get in the way of playing games. In essence, I actually thing if the boost of internals is true, this phone will be a superior gaming phone to the Bionic, even with the lack of 4G(which won't be available for me until 2013+ anyway).