I have the otterbox defender on my N2, and the Clarivue tempered glass. I did punch out the screen protector the defender came with. I just didn't like it.
The defender with tempered glass screen protector work just fine. The case creeks a bit when pulled on the side edges. But, I a hear there is an electrical tape trick to get rid of that. The Clarivue screen protector doesn't full cover the screen. A part of the bottom is slightly exposed. But the good news is there is no loss of sensitive on the scren itself. You can hardly even tell that its on, feels just like glass.
The only thing I don't like is it seems to glare quite a bit in the sun.
I also had the Xgear tempered glass screen protector. But that didn't work so well. Lots of difficulty scrolling. However it did a better job of covering the entire screen, and it got rid of the creaking on the defender case without the builtin screen protector.
Sent from my SAMSUNG-SGH-I317 using Tapatalk 2