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depends on what you mean by lose. You can get a program called titanium back, and several others (like sms backup) and you can pretty much have your rom setup exactly as it was. I always do a titanium backup, sms backup, and if i am on an MIUI rom, i use their built in backup. but i have not lost anything in a very long time. And, i can flash and be back up to 100% in 10 min!
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