A new problem , someone offer some help

Something new I began haveing problems with. I am S-OFF, unlocked and rooted, I am everything the phone can do. I was on ViperXL and things went good. Then went to a custom JB 3.18, then the AT&T official OTA came out. Being stupid I did the OTA. just to see what was good or bad about it. Except for the bloat I liked it, did the touchscreen downgrade as suggested by a dev. I got hungry for better again and started flashing customs again. Now I have this problem I can't find the solution.
When I connect usb, HTC sync gives an error, Your device is locked and needs to unlock, please unlock and restart HTC sync, or something like that and the PC can't find the HTC either by a hard disk or by using adb. This all started after the OTA update then flashing custom roms.
So can someone tell me how or where to unlock the phone if its S-OFF , unlocked, etc. For additonal information, it started doing this when I flashed CleanRom 6.1 I think and continues on with most all custom roms now.

Sounds like something went wonky in your switching between OTA/custom ROMs. If someone doesn't pop in with a solid answer your best bet maybe to make Titanium or MyBackup Root 'backups' of your important apps/data and save that off the device (on computer or dropbox, etc.. ) and then do a full factory restore and that should clear up any problems unless this is specific to the new OTA and ROMs built from it.

Once you have confirmed the problem is resolved then if you choose to unlock and root again you can restore your apps/data from your backup's.