With all of the talk of ICS and a pure android experience I started wondering if I will miss anything by not having a skin. Example, during my brief time with the bionic I had a text message while driving and the bionic ask if I would like it to read it. I thought it was great but was it the OS, skin on the OS or an app? I ask this here because I am getting my Galaxy Nexus this weekend, yeah I know someone who is related to someone who supplies Verizon with post-it notes.
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Something like that (the phone asking if you wanted it to read you a text) would be from an app (which in that case is part of the skin). Honestly what a skin over Android (at least in the sense of stuff like Touchwiz, Blur and Sense, not modded Android like on the Nook tablets or the Kindle Fire) is customized apps for everything from the launcher to the settings apps, along with a tweaked theme for everything (default images, colors, styles, etc. being changed) and different functionality being included (such as your Bionic asking if you wanted your text read out loud) - plus device-specific changes.
I guess what I'm getting at there is that in many ways the skin is all about the apps - except for the system-wide changes like style tweaks and added software functionality. What will you miss by not having a skin? All depends on what exactly you enjoy about what the OEM skin provides. A different lockscreen style? Unified inbox (which I don't see the hype for but many people apparently like)? The overall look and feel of the OS? Almost all of my experience with Android devices has been with un-skinned (i.e. "Google Experience") devices, so I couldn't necessarily answer that for you.
tl;dr What are you worried you'll miss about skinned Android?
PS. Many things you could miss from skins like Blur can be implemented with different apps, or in broad cases with custom ROMs like CyanogenMod or independent devs.
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And wait, surely you can't be serious about getting a GN this weekend - unless you're jumping ship from Verizon?