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Re: disable apps?
I think the biggest benefit is that it cleans up your app and widget drawer as the disabled apps are no longer listed there (I like it because it keeps things less cluttered). It does save a little on system resources, in particular available memory which I've seen go up on my Nexus 7 and Note 2 after disabling a bunch of apps (a reboot afterward helps ensure all disabled apps are stopped). That alone hasn't increased performance on either device that I can tell, but it keeps more available memory for other processes if needed.
Originally Posted by Todd_L
As to a list, I've disabled the following without any negative effects so far:
Amazon (two of them, 2.0.11 and 2.0.5)
Google Play Books
Google Play Magazines
Google Play Movies & TV