I just picked this up this afternoon so this is based upon just a few hours of use and my experience with the phone in the store the day before it was launched.
Aesthetics -- The phone itself is very well designed, one thing that impresses me is that the extended battery cover, while making the phone bigger does not completely distort the lines of the phone the way the ones for Thunderbolt and Droid Incredible 1 did.
Screen - Crisp and bright, what the Thunderbolt should have been. The GSII (AT&T version) has it beat but not by much and you really need to be looking at the two side by side to notice. If anything I think this one has more realistic color.
Hardware - The phone is more plasticly than I would like and does not feel as solid in the hand as the Thunderbolt does but it does feel better than the Droid Incredible 2, and is certainly NOT cheap feeling.
Phone - including bluetooth & speakerphone usage - I don't use this particular phone that way. Data only.
Overall User Interface (including HTC Sense) - It's a refined Sense. Not a lot to say about it.
Widgets - Not much to say here, it's the next evolution of Sense, works smoothly and is functional
Signal quality (Compared to other devices) -- Same average as the Thunderbolt, any Motorola phone seems better in this regard (specifically Droid 3 and Bionic I have here)
GPS - no experience yet
Social Networking - gotta love friend-stream and sense for this, seems to work a little smoother than the Thunderbolt
Email/Calendar - same as Thunderbolt
Battery Life - Bought the extended battery at 50% off but haven't actually put it through it's paces yet. It's LTE so we know it will drain the juice.
Performance - Was expecting it to be like Thunderbolt which while nice pales in comparison to Bionic but this phone is more like Bionic. This sucker is a powerful beast!
Media (music, movies, DLNA) - all I have used so far is Google Music but I was impressed. Haven't tried the Beats headphones yet but as I understand it only the stock media player will take full advantage of them,
Keyboard's - same as Thunderbolt would be nice if it had Swype but no major loss as I don't use it that much anyway.
Camera (both still & video) -- no video experience yet but the still pics are clearly sharper and have more realistic color than Bionic and Thunderbolt
How the Rezound compares to your previous smartphone (if applicable) - I kinda cover this above, all I can really say is that each new phone improves the overall experience and this one is no exception.
Disappointments (if any) - Again the phone feels a little plasticly but I can live with it, also no separate HTMI out (seems to require an adaptor and use the USB jack so you cant charge it at the same time, and yes I miss the kickstand