I've been switching between stock sense and launcher pro plus, but to be honest I find the combo of LPP with Sense the best combo over all and have kind of settled on it. For whatever reason I seem to get a lot better battery life with LPP, and I like how it's facebook widget is a separate entity from twitter/friendstream ect., I don't like that all in one thing it's just to much spam. I feel the calendar widget is also better than stock sense, since I can add an event right from the calander widget with out having to go into it, the shortcuts right on the front screen. Also the sense calander is either the monthly over view or the daily schedule, where as LPP you can also toggle easily between them.
Another thing is the ability to have a great dock in LPP, I hate the stock sense dock, only having phone, apps and customize is really limiting and whoever thought of that was a moron. Honestly, once you have your phone setup right do you really need a dedicated unchangeable button for it?? Now I've got phone, people, apps, msg, and internet all on the dock, much much better!
Since I'm not rooted it's also nice to be able to hide apps in the app drawer that I don't use, not being constantly reminded of the bloatware allows me not to be as pissed off about the wasted space that is the two holes of "lets golf" blockbuster, bitbop and all that other vzw crap I'll never use...
I also like the fact that I can make custom icons and basically theme my own phone out, since I can completely alter the appearance of the dock, icons, wall paper, and the transparency via sense. When you set your skin for sense, the underlying appearance of the notification bar and the like carries over.
So I can keep a lot of the nice aspects of sense, and I really don't miss any of the widgets.
Hope this helps!