Any app that syncs. Look at the accounts you have, and see if they are syncing and what is syncing. Then look at apps that do sync, such as Facebook, Twitter and anything else that has sync or updating in the settings. If you are syncing things every few minutes, then it will use a lot of battery.
Also there could be a glitch if you aren't syncing much and you could try a cache wipe and see if that stops whatever is causing it.