Most definitely with Sense. Software is more important than hardware.
Only if it makes the hardware better.
I would like to see this with an 8mp Ultrapixel sensor for better daylight photos and low light pics that don't lack detail. Of course, even better performance in low light would be awesome.
As for design, I'm not sure, an evolution of the current ID would be ok with me. The One is still one of my favorite devices to carry around, simply because of its looks. I hope the speakers stay the way they are, and the display get better (not sure how, maybe real color accuracy this time around?).
And of course, I want a full days use out of the battery. That varies from person to person, but I don't care if they make some amazingly efficient phone or but a giant battery in it, a smartphone should last for a days worth of use.