In terms of HTC One → Moto X, it'd be a tough call. I have the Nexus 4 and I've contemplated getting the HTC One. Its beautiful and Sense is far from garbage IMO. Compared to other skins, it ranks top for me. LG has perhaps the worst of all skins.
Anyway, I think the Moto X would be somewhat of an improvement, or at least they're pretty even. Moto X has the size and user experience, but I believe the One has a better camera and useful options Sense provides. Both good phones. If it comes down to it, you can't beat Stock Android. Just wish the camera was better. X is definitely better than the N4 though just considering LTE alone.
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