No, it doesn't "hurt" and it will probably improve your reception and battery life, especially if you go for one of th3ory's ROMs (or others out that also seem to offer improved batt life). The only disadvantage you'll have is that whenever there finally is an official OTA update, one of these days, you most likely won't be able to flash that since you'll already have some upgraded kernal and radio files. So you'll have to wait until the dev community figures out a solution (which they will) to get you there. MANY of us are in this boat and it doesn't bother me in the least.. but obv depends on your comfort level.