Not since I put it into an Otterbox Defender. I've dropped it a few times (once screen-down) and haven't had any problem.
My wife is in the hospital and has a problem holding hers, so I put my damaged case (it won't clip into the holster properly any more, so they replaced it) on her phone for now.
It's a big case, it's not cheap (around $50), but if you can throw a phone against a sheetrock wall (Accident - don't ask) without damaging anything - even the wall - it's worth it. (Lifeproof cases are just as good - and waterproof.)