I would mostly echo what's been said about the feel. I do notice the slight size differences, mostly the thickness and that the screen is slightly smaller. I also really notice the weight, but even with my N20U, I've hit a point where I feel I need to start using a grip. I have, what would I call it, Note pinky? Hahaha... it's fatigued, always supporting the weight of the phone, let alone a heavier one now.
I do, however, feel the S22U is more balanced in the hand. Since the weight is spread out and lacks the significant camera hump, I find it more comfortable in that regard vs the top heavy N20U.
The size will probably not be as noticeable if I wasn't holding the two side by side, which I will continue to as I plan to keep my N20U for work. Plus, S22U comes with a better battery so it's a trade-off I can appreciate.
I also love the matte spen, I didn't think I'd care, but it's less slippery which I appreciate. Although, maybe it's just my unit, but it doesn't glide in and out as nicely (not difficult, but it drags/skips during removal).
Like Katrina, though, I'm not feeling that excitement of a major upgrade. I hope I continue to be happy and see no issues, then I'll send my N10+ (bye bye gorgeous blue) and keep it pushing, using both N20U and S22U.