First of all, I'm not here to bash either Apple or Samsung. I enjoy both products and have owned numerous devices from both companies. I just wanted to give an honest review to someone who can't decide on which new phone to get. I wanted to give some real world pros and cons of every day examples that might not be too obvious to some. These are my personal opinions only and others may disagree or agree 
Look and feel: They are both similar in size, I recommend having a case for both devices as they both feel too slippery without one. Aesthetically, the Note 5 is much nicer to look at with the curved side edges and glass back panels. The 6s Plus looks great but I'm not a fan of the outlined antennas on the back. The Note 5 is much easier to navigate and quicker to do everyday tasks (I will explain this later). I think the iPhone 6s is a better size between the two - you need to really use two hands for the Plus since it's so big and doesn't have a convenient back button. The fingerprint censor is a lot better on the iPhone (by a mile) - much quicker and naturally placed.
Camera/Photos: Honestly, they both take great photos. If someone was to send me photos taken from the exact same location I wouldn't be able to tell the difference. I do prefer the speed and convenience of Note 5's camera - you simply double click on the home button whereas in apple you need to either unlock, click on camera or click on home button and scroll up (camera shortcut). I also like how the Note 5 uses the full screen as the viewfinder whereas the iPhone you lose about a quarter of the screen. The new Live Photos feature is pretty cool and the slow motion shot is much better on the iPhone.
Battery Life: I would say the battery life itself is a little bit better on the iPhone. The lighting cable is more convenient than the usb since there is no right or wrong way. However, the quick charge on the Note 5 makes a huge difference. Forgot to charge your phone at night? Just plug it in before you hop in the shower and you are back at 50% easy.
Customization: Again, this is where Androids shine. Yes, you can jail break the iPhone but then you risk warranty etc... I still hate Touch Wiz (even though it has gotten a lot better) so I use Nova. It takes a bit to customize to your liking but in the end you can't beat the amount of customizations you can make on the android to speed up your efficiency/productivity.
Apps: Apple by a mile. Apple has better quality apps (especially games) and a better designed app store. The play store is a mess and too many steps required to see what's new and updated.
Text Messaging: iMessages > Standard SMS.
Multitasking: Note 5 > *. True multitasking.
Keyboard: I find Apple's keyboard a bit more precise and efficient.
Bloatware: Samsung is known for bloatware but I find Apple to be equally bad. "Watch" app comes preinstalled which cannot be deleted. Same with Keynote, Stocks, Pages, Numbers, iMovie, Find Friends and News which I never use.
S Pen: I don't find the S Pen that useful but a neat feature to have for note takers.
3D Touch: Honestly, I think this feature is a bit overrated. For example, if you "hard press" on the phone or messages icon, you get a list of recent or favorite contacts. You can achieve the same action by creating a shortcut of your favorites on your home screen, which is technically faster. It is a nice feature to have inside Mail which allows you to preview your messages before opening them but I don't really find myself using this feature as I generally know which emails I want to read.
I could keep rambling on but I just wanted to share my thoughts.

Look and feel: They are both similar in size, I recommend having a case for both devices as they both feel too slippery without one. Aesthetically, the Note 5 is much nicer to look at with the curved side edges and glass back panels. The 6s Plus looks great but I'm not a fan of the outlined antennas on the back. The Note 5 is much easier to navigate and quicker to do everyday tasks (I will explain this later). I think the iPhone 6s is a better size between the two - you need to really use two hands for the Plus since it's so big and doesn't have a convenient back button. The fingerprint censor is a lot better on the iPhone (by a mile) - much quicker and naturally placed.
Camera/Photos: Honestly, they both take great photos. If someone was to send me photos taken from the exact same location I wouldn't be able to tell the difference. I do prefer the speed and convenience of Note 5's camera - you simply double click on the home button whereas in apple you need to either unlock, click on camera or click on home button and scroll up (camera shortcut). I also like how the Note 5 uses the full screen as the viewfinder whereas the iPhone you lose about a quarter of the screen. The new Live Photos feature is pretty cool and the slow motion shot is much better on the iPhone.
Battery Life: I would say the battery life itself is a little bit better on the iPhone. The lighting cable is more convenient than the usb since there is no right or wrong way. However, the quick charge on the Note 5 makes a huge difference. Forgot to charge your phone at night? Just plug it in before you hop in the shower and you are back at 50% easy.
Customization: Again, this is where Androids shine. Yes, you can jail break the iPhone but then you risk warranty etc... I still hate Touch Wiz (even though it has gotten a lot better) so I use Nova. It takes a bit to customize to your liking but in the end you can't beat the amount of customizations you can make on the android to speed up your efficiency/productivity.
Apps: Apple by a mile. Apple has better quality apps (especially games) and a better designed app store. The play store is a mess and too many steps required to see what's new and updated.
Text Messaging: iMessages > Standard SMS.
Multitasking: Note 5 > *. True multitasking.
Keyboard: I find Apple's keyboard a bit more precise and efficient.
Bloatware: Samsung is known for bloatware but I find Apple to be equally bad. "Watch" app comes preinstalled which cannot be deleted. Same with Keynote, Stocks, Pages, Numbers, iMovie, Find Friends and News which I never use.
S Pen: I don't find the S Pen that useful but a neat feature to have for note takers.
3D Touch: Honestly, I think this feature is a bit overrated. For example, if you "hard press" on the phone or messages icon, you get a list of recent or favorite contacts. You can achieve the same action by creating a shortcut of your favorites on your home screen, which is technically faster. It is a nice feature to have inside Mail which allows you to preview your messages before opening them but I don't really find myself using this feature as I generally know which emails I want to read.
I could keep rambling on but I just wanted to share my thoughts.
