It's all in the eyes (hands) of the beholder.
I don't think I have large hands, but everybody is different. I guess I must have fairly large hands since I have to usually buy large or x-large gloves for the winter (side note: winter is going to be interesting again... but I usually don't wear gloves except to scrape the car windows or remove snow from my car). I think seeing as all the new phones are getting bigger and bigger, this is what future phones are going to be... adapt, they are coming. I'm sure we will see less and less smaller phones, which could be a bigger issue for more and more ladies and some men.
Notifications have been my biggest issue with taller phones (the HTC One, I think it was the M9 as the second edition was my first)... but I replaced my launcher with Nova and can use a single swipe down to get to my first notification from any where on the screen - this really helped that I did not have to go all the way to the top of the screen to get them. So, I loaded Nova with in minutes of getting my new 6P. It's just something I find helps.