When I first had my Note 10.1 I tried it without a screen protector and it felt really slippery writing on just the naked screen(Could be because I wasn't use to using a stylus that wasn't thick like the Ipad ones I used). I had an Ipad 3 awhile back, hated it with a screen protector, so went naked on that device. Was a totally different feeling writing on the 10.1 with the S Pen without one. I was used to using a rubber tipped stylus on the Ipad 3, which gives it some drag. Once I put the Miniguard screen protector on my 10.1, it felt not as slippery to me, but it doesn't affect the way the S Pen works. They are thin enough, where it doesn't really affect the use of it. I like the feel of having a little more traction with the S Pen rather than the slippery feel of writing on the naked screen on my 10.1. I do mostly drawing on it and use the Pen to hit icons and navigate the screen, so doesn't hinder at all.