IMO no not really worth it, I've rooted and flashed several ROMs on my past devices, first of all, think of why you want to root it:
- if there's an app on the Play store that requires root, I used Volume+ on my last device (LG Optimus LTE) because the call volume was too low and it required root which was easy to do on that device. And I also had a screenshot app which of course needed root.
- a ROM that meets your preference, 4.1.1 for me does everything I need including making fonts larger, which wasn't possible before ICS.
Rooting the One X is no cake walk, my Asus tablet isn't easy to root either and I lost it after an OTA update and can't root anymore.