Well my friend, after leaving BlackBerry phones I moved to Google Android Platform. HTC One X, HTC One X+, HTC One( M7) were my first Android phones. At their chronological moment all three were the Flagships of HTC. Your question is a valid one but I'm afraid don't know the answer. Your HTC 10 is a new phone and it is fast just at stock Sense. But if you feel, think or see that your phone runs faster with TSF Launcher good for you because your Android experience is what matters here. Lets see, my current phone is a Samsung Galaxy S6, I bought it on May 6, 2015 at my Mobile Carrier AT&T. Some Samsung users before the S6 said that when they use Nova Launcher their S5, S4, S3 runs faster than the stock Touchwiz. That's not the case with the Galaxy S6 and the new S7 because stock Touchwiz is fast, no lags. You must take in consideration the Mobile Carrier were your HTC 10 runs, good mobile signal is a must for a fast phone regarding calls, text messages, e-mails. A good router combined with a good WIFI service is a must for a phone connected to it cause it's going to be fast.
When I bought TSF and Lighting Launchers my experience with both of them was kind of funny crazy thing, to complicated and difficult Launchers. I don't use them. For the big majority of Android phones users the best Launchers out there are Nova in the first place and Apex in the second place. But for you, right now, the best and fast one is TSF. I don't know if Lightning Launcher runs faster that stock Sense, what I know is that if you deal and enjoyed TSF Launcher you are going to enjoy Lightning Launcher. It's so difficult and complicated that you are going to play, fight and win over it the same way you win over TSF Launcher. Then you must buy Next Launcher (check out the screenshot) this one is beautiful. What Launchers I use ? ADW and Lollipop cause for me and my personal Android experience this two are the best.
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