Anyone else having this issue? It's not all of the time, but I would say that 25% of the time, I have to hold my finger on whatever I want for up to a couple of seconds, to actually get it.
Are you using a launcher such as LPP or ADW EX? If so did you add more rows or columns? That's the only time I have trouble long pressing icons or widgets.
If not you can try using HTC calibrate, it's an application made by HTC to adjust touch screen accuracy. I use it on my DX whenever I think the touchscreen is off.
I have to agree with this. Everything seems responsive, smoother and faster. I also agree with @Finsol I've always found that if I use LP or ADW my touchscreen is a little wonky.