Why doesn't my home button work anymore?

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Hello, 1 or 2 weeks ago, I updated my nexus 5 to android Marshmallow 6.0 through OTA. Eveything was working fine until today, The device rebooted by itself and I lost access to my quick settings through notification and the home button became useless, it doesn't do anything when I click it but if I hold it, Google Now on Tap works fine. When I opened a guest account, everything worked fine. After returning to the main user, quick settings was working again but the home button still doesn't work. What is the solution?