I had wondered about this myself. Although my storage sizes are less than yours, I seem to have a similar experience.
I had a 16 GB Sandisk (nothing particularly outstanding about it), which worked perfectly fine, but I needed more storage space. So I got a 32 GB card (don't remember if Sandisk or Samsung). Copied all my music over and started experiencing skips and dropouts. Checked genuineness using SDInsight to make sure I didn't have counterfeits; and the card was legit. I then went and bought another 32 GB, this time an industrial grade card used in manufacturing and professional applications made by Delkin (not a popular name like Kingston, Samsung or Sandisk) which was Speed Class 10, UHS Class 3, 50 mb/s write and 99 mb/s read (not the best in 2016 but was impressive in early 2015). The skips were reduced but not entirely gone. Yep, I was a bit miffed but decided to live with it.
That said... I also have a secondary unsubstantiated theory. It SEEMS like the dropouts occur when wifi is connecting or some other radio function is happening. I wonder if the radio chip (which I understand handles wifi, bluetooth and mobile data) causes BT to drop out when wifi is trying to connect or disconnect...?