Yes!!! Definitely! I use my Droid differently through the week than I do on the weekend. Have had to compromise with my screens setup to be able to keep what I need in front of me. Brilliant!
If others could use it, sure. Even after jumping to a X in Dec. I'll still be carrying a BB Tour for my job, so as far as my Droid will be concerned, everyday will be the same.
I think what I would really like is to be able to do that with LauncherPro...
I'm working on one of those "android phone 7" themes, but I still prefer the android layout. I would just like to be able to switch to and fro without using adw