Apart from the loss of MST, the S22U is an improvement over the N20U in just about every practical way (for me.)
One thing that hasn't been mentioned (or discussed much) is that the main camera appears to have gained back dual-aperture focus. Now when I take pictures of documents or other objects that require edge-to-edge focus, I actually succeed, whereas it was a 100% failure rate with the Note 20U's razor thin depth of field, where even a tilt of the phone would cause parts of the object to appear out of focus. In One UI 4, Samsung even added an on-screen message (on N20U) suggesting to step back and take a picture with the telephoto lens for a clearer picture of text.
As much as I loved the 5x optical zoom, I love the 10x even more (2x more to be precise.) Taking videos of my kids during sports is even more enjoyable now.
Really glad I made the jump