1) I just discovered I can't get into SAFE MODE on my LG G4. That's because it is unocked via "USU" method, and that process takes over the original SAFE MODE key combination, putting you into the TWRP recovery instead. I don't know that there's a workaround for this.
2) I SOLVED THE PROBLEM! (So I'm posting in case anyone has runs into something similar, because this is a weird one...):
Problem: I discovered the audio was fine after a reboot, especially system sounds. But whenever I plugged in my headphones and listened to music files, I'd hear a loud constant screeching noise, like Chewbacca having a hairy fit, no matter the music player. It would stay that way until a reboot!
Solution: I thought it might be due to leftover files from a couple of failed Magisk module installs (Dolby Atmos and Volume Steps), which did not install. But perhaps left bits of themselves in the system folders?... I rooted around those folders and deleted whatever looked like it might be remnants of those modules. Didn't solve it. Then, using a system freezer app (Uninstaller Pro), I froze anything and everything that looks like it might be related to audio. Which led me to discovering that the culprit was "Audio FX". Some kind of audio processing app, that is built into LineageOS and Cynaogen.