I have experimented with "battery conditioning," "topping off" and changing wall chargers. Here is what I have determined through a process of elimination. First, I should say that everyone's EVO 4G is different due to downloaded apps and other configuration elements. Everyone's solution may also vary but I believe my findings will apply to a broad range of users.
Many users have experienced a rapid drop in battery charge within the first 10 - 20 minutes of taking their phones off the wall charger - this seems to occur primarily when the phone is left on the charger overnight. As a result, many users start their day with anywhere from a 10% to a 20% battery handicap.
It is undeniable that the phone and wall charger work in such a way that when the phone reaches 100% charge, the phone goes onto battery use with no trickle charge at all. Your phone is running on battery. The drop of 10% - 20% in the first 10 - 20 minutes is not actually a drop; rather, it appears this is the phone going to the true battery charge that was initially misreported.
"Topping Off" works to a limited extent, especially if the phone is removed from the charger just as soon as the led goes green. I strongly suspect the same is true of the original charging session; that is, if the phone is removed from the charger just as soon as the led goes green. (hard to do if you're asleep)
I also suspect that what is described as "battery conditioning" also works because the phone is removed from the charger just as soon as the led goes green.
The last item I looked into was the wall charger itself. I read a post by someone (I wish I had noted the name so I could give credit) who suggested these problems seem to go away when you stop using the OEM HTC wall charger. Like me, that user also had some Palm Pre wall chargers that he used. In my case, I also have some cheap aftermarket Chinese wall chargers. Using a process of elimination I have confirmed to my own satisfaction that when using the OEM HTC wall charger this initial drop in battery during the first 10 - 20 minutes is the most pronounced. When I used either my Palm Pre or the cheap aftermarket wall chargers, the problem was entirely eliminated. I strongly believe that HTC has a problem it should address with its OEM wall charger. Ironically, you can buy inexpensive aftermarket wall chargers for less than $10 that will cure this problem.
I now reserve that cable for PC connection and no longer use it for charging my phone.