If you don't want to use Sense, you don't need to uninstall it, just install one of the launcher replacement apps.
If you want to get rid of Sense completely, you'll have to wait for someone to create a custom ROM that doesn't have it included and works for the E4GLTE after you're rooted.
It's been quite some time since I've used another launcher, so I'm not sure... I think Sense would drop out of the memory and stop running in the background, but I cannot confirm it.Thanks Glenn. Will Sense still be running in the background if I use another launcher?