I moved from a GS4 to a Note 4 and my fiancee moved from a iPhone 5 to the 6+. We both thought it would take a lot of getting used to but it was actually easier than expected. You really do get used to the size. Yes, one handed use can be a little bit tougher but for a lot of things (like texting), you can easily adapt (especially with different keyboards). The size of the screen more than makes up for it. I see people with smaller phones (mostly iPhone 4 and 5) that feel damn near toy like when you try to use it. If you wear skinny jeans and have to pocket your phone though, it's probably not a good idea to go with a phone this big. I don't wear skinny jeans so it's not really an issue, lol.