I moved from a tired Gen1 Ipad to a Nexus 10 around 8 months ago. At first I had challenges getting use to the N10, but once I got use to it there was no turning back.
The small challenges I have faced are that some of the television shows I purchased from Itunes are not available on Goggle Play (smithsonian channel stuff). Just now I am listening to a book via the Audible app (latest version of Android - 4.3 installed) and there are three persistent notifications in the notification bar due to issues between the app and the new version of software.
However, when my non-geek wife was looking for a pad, I pointed her to an Ipad Mini. For her the simplicity / walled garden of the Ipad was the best choice. For me it would have been like going back to jail. If she has a problem with the Ipad she can walk into the Apple store, something that the Google brand does not offer.
IMO the "best device" is different from person to person. If you want simple with support and few choices - go with an Ipad. If you want more control and a thousand ways to customize your experience - go with an Android device.