Everyone who said they will read the manual... just wondering, what OS are you coming from, or are you coming from a feature phone?
I have never owned an Android phone, but I have setup my dad's Cliq, my friend's Moto Droid, and another friend's Incredible, and another friend's Hero. I never went through a manual, but it was a breeze (note, that's Android 1.6, 2.0, and 2.1 versions I played with) to setup email/gmail accounts, widgets, power settings, etc without having to read up on it.
I do have to admit, I would take new manuals into the bathroom for perusal (I mean... I have to have SOME kind of reading material... oh, and apologies if this is TMI =P) but I never felt that it would be necessary to operate the phone.