Another good explanation GeorgeChief! Any Knox stuff is in it's own little world.
Another tid-bit, if anyone is thinking about rooting, it will trip the Knox counter and Knox will not work. Root is considered a breach in security.
Even where I work, and we don't use Knox, we have a BYOD program set in place, and rooted android devices can not get exchange mail through AirWatch.
Personally, I'm still on the fence about rooting the S6. Some devs over at XDA with previous devices running Knox, have been able to root without tripping it. So I might wait until they figure out the S6 to do the same.