I was curious if there are any issues doing this? I'm running the Sprint Lovers ROM and I just did the PRL update for the hell of it, I'm currently at PRL version 60676.
The only thing you shouldn't do is an "HTC Update" i.e. OTA update. That will break your root and may be patched to require an alternate method to root.
OT, seeing thefredelement's avatar and his short answer, I couldn't help but think of a song by "A Tribe Called Quest."