I am having severe trouble with the touch sensitivity on the phone. Timing just about coincided with the 4.3 update. I am in the process of trying to contact Google to help with the problem. But the latest is they have blown me off. Also opened a discussion thread on the google forums. and to my horror finding out tons of people are having the same issues.
https://productforums.google.com/forum/#!category-topic/nexus/nexus-4/4ER2V5RMuG0
https://productforums.google.com/forum/#!categories/nexus/nexus-4
https://productforums.google.com/forum/#!category-topic/nexus/nexus-4/4ER2V5RMuG0
https://productforums.google.com/forum/#!categories/nexus/nexus-4