Defender case has built in protector. I should be getting mine from Amazon tomorrow and it's on sale right now too! These cases are VERY hard to find in stores for the edge they're popular I'm told and especially with the Note debacle and some switching to the edge. I hear the screen protector fits a lot tighter than the other Otterboxs for other phones too so dust does not get inside as much. We shall see. If not I'll order something else and go naked like I did with the Note 7. One bad thing about the curved screens of the S and Note series this year.
I bought the Defender and ended up taking the built in protector out. With it in, I lost a lot of touch screen sensitivity. Edges of the screen were almost useless. That was just my experience.
I will say that taking the built in protector out may not be the best option though. It does mess with the function of the volume and power buttons.
For now, I'm back to my SupCase Unicorn Beetle Pro with my Skinomi screen protector. Works fine. I don't think it offers the drop protection of the Defender though.