I had some problems using the 64gb I got from SanDisk even when NOT connected to the device. Putting it in my card reader, which is compatible with SDXC and worked fine with a Kingston 64gb, saw it "time out" periodically. It did so even more often when used in the phone. Sometimes it seems fine. But I was always wondering when I was going to get another "can't read card" message. Still, I ultimately managed to get 55 gb of stuff transferred. Most worked, especially if I unplugged the phone at times and in essence rebooted the USB connection. I did find at times for more limited stuff that it might actually be easier to copy to the phone and then use the phone's file manager to move to the card.
You say you're connecting S4 to MacBook? I have 0 experience with Apple, which may add other issues.
NB: once everything was copied, the card itself works perfectly in the S4. There have been no errors, no issues.