Launcher Pro FTW!
... but seriously the BEST way to decide if you want to move from HTC Sense to a launcher is to TEST them. Fortunately, the launchers are FREE. If you don't like them, they easily uninstall and you are back to good old HTC Sense.
Test them out, and come back to tell us what you think. (c:
Let me share some reasons why I like Launcher Pro better than HTC Sense.
1. The app drawer scrolling is SOOO smooth, I like the 3D effect too.
2. I like the option of being able to fit 5 rows instead of 4 rows on each screen.
3. I am able to choose how many screens I want.
4. I love the bottom dock! It makes much more sense to me than having HTC's "dock" with a huge phone icon, an app drawer launcher, and a useless icon used to add widgets etc.
5. Another huge win for me is for uninstalling an app, go to the app drawer, tap and hold an app, then drag and hold it in the trash bin until you see a message "Drop to Uninstall". A lot faster and easier than the Market or App Manager.
One thing I wish you could do with Launcher Pro is use HTC's widgets, but I got over that in a few days and found some excellent replacements.
Good luck, and have fun.