It really varies person to person and by their hand shape/size, and what they feel is "comfortable". The Note 3 is comparable to the Note 2 in size. I think it might be slightly thicker/longer but not by much. So to judge yourself, visit any store with a Galaxy Note 2 and feel for yourself. I don't consider myself to have large hands by any means but playing with a Note 2, it was surprising I could pretty much control whatever was on screen with just one hand. Some things might not be as comfortable as a smaller device, or moving an icon from the lower right to upper left with maybe a thumb would be hard, but overall I felt it was pretty accommodating.