I have the defender on my DNA and I removed the plastic screen after a matter of hours. It wasn't even just the desensitized screen, but the give beneath the screen when pressing that drove me insane. I didn't like the feeling of air between the protector, the glass, and my finger. The case is a little looser since removing the screen but not noticably so to the point that the case doesn't fit the phone. Its more of a little creak on each side. The case still fits the phone perfectly and I am much happier with my purchase now that I've removed the screen. I kept it incase I ever decided I wanted to reattach it but I highly doubt o ever will. I have removed the cover frequently to show the difference between naked and cased and the silicon is as rigid as always.
Sent from my HTC6435LVW using Android Central Forums