I've had this problem on a few of my phones and it's compounded by the fact that I work outside and I'm often in extremely dirty and dusty environments. I bought myself one of those little electronic equipment vacuums that's rechargeable off of Amazon, I think it was about 8 bucks. It works perfect for cleaning all of the exposed ports on your phone! I wouldn't wipe them down, you might force things into the speaker grill rather than getting it out. The vacuum came with all kinds of attachments, one of them is a little brush and the other one is a very small tube that actually fits inside the headphone jack and the charging port
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