Yes. But it is far rarer for me. Has only happened once so far. I noticed it was draining at something like 10% per hour all of a sudden for no reason and nothing had changed. I rebooted it and the phone and it was back to normal.
Seems like my Nexus 5 phone does the same thing every several weeks. I never reboot it, until that mysterious drain starts... reboot it and it is back to being fine again for several more weeks.
It is stupid that rebooting requires root, because otherwise it would be nice to have an app that would just reboot it every X days at night or something.