I made the move from the Evo3D a couple of weeks ago.
I missed HTC Sense at first, some might say it is nicer to look at, but after playing around with different "launchers" - go launcher at the moment, I miss it less and less.
The #1 thing I like is the battery life is fantastic compared to the 3D. I only had the 3D for the six months or so it was out and I had to basically have it plugged in half the day at work, then charge it up overnight at home. And this was with minimal usage.
With the Epic I have been able to do more and actually enjoy using my phone and all of the apps out there without having to worry about battery life! I use the phone, text, FB, check emails, surf web, use pandora for a few hours and still have 30-40% or better battery life by the end of the day!
Very happy with the phone.