I had the problem of Go launcher crashing on an unrooted htc Inspire. By crashing I mean that about once every few days The phone would completely lock up when certain apps were open. All tactile buttons would become unresponsive, even the power button, and the only way to restore function was to remove the battery. I uninstalled Go launcher a few days ago, and have not had the problem running stock sense UI.
Rooting would probably alleviate the problem but I'm not sure if I really need Go launcher that badly. I really did like it when it worked though. Another launcher I liked was the Regina launcher, it was really buggy though.