New one on me. Turn on developer options and ask it to "show touches" so you can see exactly how the screen is interpreting your input. That may give you enough clues as to whether the problem is really isolated to a specific spot or not.
Could be something on the screen that needs to be cleaned off, so you can try giving the screen a thorough cleaning with a gentle cleaning solution and then wipe it down with a microfiber cloth.
Could also be some bad app causing severe enough lag that things are getting confused.
Sadly, could also be something going wrong with the digitizer/touch sensor.
Knowing nothing, my solution would be, in sequence assuming each step does not help:
1. Clean the screen.
2. Run a sensor testing app or simply start a paint program and draw thoroughly across the whole screen trying to narrow down specific spots that are problems.
3. Uninstall most background apps.
4. Factory reset.
5. Replace digitizer (or, more likely, tablet)