I have both (for now

) and agree with everything that's already been stated by others.
There's a lot (A LOT) that the S22U does better then the 6 Pro, but I am finding out year after year as I purchase Sammy's latest and greatest that I just prefer the Pixel experience.
Here's my personal pros list for the P6P:
* I take a lot of indoor pics and the Pixel is just more reliable for me. Love the features and versatility of the Samsung camera and wish Google would add some similar features, but when it comes to trying to capture a quick moment with simple point-and-shoot, for me the Pixel wins every time.
* I do a ton of voice to text and there's just no comparison between the two! Pixel is just leaps and bounds better in that aspect.
* Samsung also appears to have disabled the ability to snooze texts in Google Messages, something I use often.
* Pixel call screening and hold for me are also things I use quite a bit.
* Battery life for me was very similar on both.
* I'm fortunate with the 6 Pro I guess as I've never had signal/connectivity issues or issues with the FPS.
If I am being honest, there are way too many pros to list for the S22U ... There's a lot of features it has I really like.
Has it been a perfect experience for me with the 6 Pro? Not even close! But I used the S22 Ultra for 6 days and then put my SIM back in my 6 Pro and there's nothing I personally find myself missing about the S22U - besides the display! (It's so bright and beautiful LOL). The Pixel 6 Pro display is no slouch, but Samsung is the display king!
In the end, only you will be able to determine which device is "better". My advice is to get it, use it and then make your own assessment based on your needs and how you use your phone ... Then you'll know which one is better for you.