I personally enable Power Saving mode throughout most of the week (unless I need a boost in processing power), BUT I mix it with a profile app. One of which I like it Llama (but there are a few others).
You set profiles that do a variety of functions based on your selection, location, time of day, or other apps running. I did a pretty extensive post a while back, but long story short, it brought my battery life from about 1 1/2 days to 2 days a lil extra, so roughly a 25% increase on battery life.
Bare in mind that my Llama does all types of things such as disabling Mobile Data when I'm around my home/work wifi, lowers screen brightness to 10% and disables wifi and data from 10p to 5am because I'm asleep anyway, and on and on. I will say, set up takes a while, but the more time you spend bettering the profiles, the more beneficiary it'll be for the user.
I stopped using those battery saving apps because they were always trying to sell me crap and had advertisements. Llama is free and I've yet to see a single ad. Alongside that, I get direct control w/ Llama, where as I don't get nearly as much control w/ battery saving apps. I'm a bit of a control freak.