First off, have you tried Safe Mode and seeing how your phone does then? This can help identify if it's an app related issue. To enter safe mode, long press the power button while the phone is on then long press on Power Off and you'll be given an option to reboot into Safe Mode. Try this to see if you still encounter battery drains.
Which cellular network are you using? Also, how does it rate on Root Metrics in your area? Those spikes could maybe be cell tower overload during peak hours, which can cause your LTE modem to pull more juice as it's trying to keep a stable connection. The closer you are to a tower, the less this happens.
Sent from my Nexus 5 using Tapatalk
Thanks for the suggestion. Unfortunately, I'd have to run in Safe Mode for a long time as this happens randomly every few weeks. If you look at the OP date and my latest update date, you'll see a few weeks have passed. THat's how long I had to wait in order to witness this bug happening again. I just don't see how it is an app, though. I run more or less the same programs every day (my usage is very routine now, nearly down to a science) and I haven't installed anything new. I don't believe it's the carrier either because I've been with Tmobile since owning the Nexus 5, and during the good days (which are 95% of the time) the battery drain is perfectly normal and fine. Check my OP, you'll see examples of what the graph looks like on fine/most days.
It's perplexing and annoying; there's no discernible culprit. It makes it hard to pinpoint what the problem is. My usage and signal strength and apps and all are nearly identical on both good and bad days -- just once in a while, a bad day will creep it's head and my phone will drain much faster. After a reboot, it's back to normal despite all the conditions remaining the same.
I don't know. Something is amiss, and I can't help but feel it's Android. I'm not the only one experiencing this bug either. Another thread that's active right now is going through more or less the same issues: http://forums.androidcentral.com/google-nexus-5/353838-nexus-5-another-battery-drain-thread.html